Metabolic Medicine

Metabolic Medicine

Is It Really Menopause?

Or Is It MCAS?

Lou Chalmer's avatar
Lou Chalmer
May 24, 2025
∙ Paid
Photo by mojtaba mosayebzadeh on Unsplash.

Menopause has long been framed as an inevitable rite of passage for women in midlife: a period of hormonal adjustment marked by symptoms like hot flushes, sleep disturbances, mood swings, and weight gain. Women are often told it’s something simply to be endured.

Not so fast.

While some discomfort is to be expected as oestrogen and progesterone levels decline, the degree of suffering many women experience today often far exceeds what would have been considered ‘normal’ in previous generations.

This begs an important question: are these symptoms purely hormonal — or is there something else at play?

Increasingly, evidence suggests that for a significant number of women, the distress attributed to menopause may in fact reflect an underlying condition that dysregulates the immune, nervous, and endocrine systems: mast cell activation syndrome (MCAS).

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